Senior Scientist, Protein Engineering and Novel Modalities, Biologics Engineering, Oncology R&D
AstraZeneca
- Gaithersburg, MD
- Permanent
- Full-time
- PhD + 0-3 years’ of experience in Chemical or Biological Engineering, Biotechnology, Molecular Biology, Biochemistry or other relevant scientific field with experience in protein engineering and/or bispecific antibody technologies
- Extensive hands-on experience in molecular biology and antibody/protein engineering
- Proven ability to work independently, effectively plan and organize work activities and prioritize task completion to meet project deadlines
- Deep understanding of various imaging/multicolor flow cytometry-based instruments and data analysis programs
- Comprehensive experience in tissue culture techniques and functional cell-based assay development
- Demonstrated experience in optimizing/troubleshooting protocols with a problem-solving mindset
- Understanding of protein and antibody structure-function relationships
- Experience in engineering antibodies with improved properties (e.g., affinity, solubility, and other attributes related to developability)
- Experience with bispecific therapeutics, e.g. T-cell engagers, ADCs, checkpoint inhibitors
- Background in antibody discovery using one of several display-based technologies
- Excellent written and verbal communication skills and effective presentation of complex scientific data to cross-functional and senior management